Nottingham Forest manager Billy Davies will recall several first-team regulars, such as Lee Camp, Chris Gunter and Dexter Blackstock.
Captain Paul McKenna is hoping to play some part for the first time since suffering a knee injury in early March.
MATCH PREVIEW
A run of only one defeat in nine matches saw Blackpool claim the last play-off spot and the chance to claim a place in the top flight for the first time since 1971.
They will want to make home advantage count in the first leg against a Nottingham Forest side that missed out on automatic promotion largely because of their poor away form in the second half of the season.
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Blackpool are unbeaten in nine at home, while Forest have not won away since January. All 10 of the Reds' most recent victories have been at the City Ground, where the second leg will take place on Tuesday evening.
Blackpool have enjoyed three previous triumphs in the play-offs, but they have been less kind to Tangerines boss Ian Holloway, who tasted defeat while manager of Bristol Rovers and Queens Park Rangers. He will be hoping for a case of third time lucky.
So too will Forest, who are looking to get back into the Premier League after an 11-year absence. They have twice been in the play-offs but failed to reach the final, losing against Sheffield United in 2003 and Yeovil three years ago.
Forest boss Billy Davies has had his share of play-off agony, losing out with Preston in successive reasons. But he took Derby up in 2007 and is now looking to follow in the footsteps of Brian Clough by leading both East Midlands rivals to the top flight.
MATCH FACTS
Head-to-head
• This is the 75th meeting of these clubs. Forest have won 28 and Blackpool 24, with 22 drawn.
• Forest have won only one of their last eight matches against the Seasiders.
Blackpool
• This will be Blackpool's sixth play-off campaign, and their first at Championship level.
• The Tangerines, who ended the regular season in sixth place, have won nine and drawn three of their previous 14 play-off matches.
• The team finishing sixth has won promotion to the Premier League in four seasons out of 18, but not since West Ham in 2005.
Nottingham Forest
• Forest, who finished the regular season in third place, have won one, drawn one and lost two of their previous four matches in the play-offs.
• They are without a win in 11 away matches.
• The club finishing third has gone on to win promotion to the Premier League via the play-offs five times, including in three of the last four seasons.
MOST RECENT MEETING
Blackpool 3-1 Nottm Forest (17 April 2010)
Blackpool scorers: Adam (pen) 32, Campbell 54, 84.
Forest scorer: Garner 65.
Source: BBC Sport
Source: BBC Sport